Thermo Fisher Scientific Stat5 Polyclonal Antibody
STAT5 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 ELISA에 사용 가능. Human, Mouse, Rat에 반응하며, Affinity chromatography로 정제됨. -20°C에서 보관하며 반복적인 동결-해동은 피해야 함.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:25,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to residues near the carboxy terminus of mouse Stat5a protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge if product is not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
This antibody is specific for mouse Stat5 protein.
A BLAST analysis suggests cross-reactivity with Stat5 from human, mouse, and rat based on 100% homology with the immunizing sequence.
Cross-reactivity with Stat5 from other species has not been determined.
Target Information
The STAT5 protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT proteins are phosphorylated by receptor-associated kinases, forming homo- or heterodimers that translocate to the nucleus to act as transcription activators. STAT5 mediates responses to ligands such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and various growth hormones. Activation of STAT5 in myeloma and lymphoma associated with TEL/JAK2 fusion is independent of cell stimulus and is essential for tumorigenesis. The mouse counterpart induces BCL2L1/BCL-X(L) expression, suggesting an anti-apoptotic role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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