Thermo Fisher Scientific ABCA1 Polyclonal Antibody, HRP
ABCA1 단백질을 인식하는 HRP 결합 폴리클로날 항체로, Western blot, IHC, ELISA 등 다양한 응용에 적합합니다. Rabbit IgG 기반으로 고순도 항원 친화 크로마토그래피로 정제되었으며, 인간 및 다종 반응성을 보입니다. 연구용 전용 제품입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-Dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent |
| ELISA | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Chicken, Horse, Hamster, Human, Mustelid, Mouse, Non-human primate, Pig, Rabbit, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Partial peptide sequence (peptide used resides somewhere between a.a 1100–1300) of the human ABCA1 gene. Actual immunogen sequence is proprietary information. |
| Conjugate | HRP |
| Form | Liquid |
| Concentration | 0.66 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | No preservative |
| Storage conditions | 4°C, store in dark |
| Shipping conditions | Wet ice |
| RRID | AB_11151837 |
Target Information
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester deposition in the reticulo-endothelial system, and deviations in cellular lipid trafficking.
ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux.
Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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