Thermo Fisher Scientific ABCA1 Polyclonal Antibody, Biotin
ABCA1 단백질을 인식하는 Biotin 결합 토끼 다클론 항체입니다. Western blot, IHC, ICC, Flow cytometry, ELISA 등 다양한 응용에 사용 가능합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS에 0.05% sodium azide를 포함하고 있습니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | - |
| Immunocytochemistry (ICC/IF) | Assay-Dependent | - |
| Flow Cytometry (Flow) | Assay-Dependent | - |
| ELISA | Assay-Dependent | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Dog, Chicken, Horse, Hamster, Human, Mustelid, Mouse, Non-human primate, Pig, Rabbit, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Partial peptide sequence (residues 1100–1300) of human ABCA1 protein. Actual sequence proprietary. |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.81 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155833 |
Target Information
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) are associated with Tangier disease (TD), an autosomal recessive disorder characterized by an absence of plasma HDL, accumulation of cholesterol esters in the reticuloendothelial system, and altered cellular lipid trafficking.
ABCA1 mediates the apoA-I–dependent export of cholesterol and phospholipids from cells. It is expressed on the plasma membrane and Golgi complex and is regulated by cholesterol flux. The balance of cholesterol flux between HDL and macrophages is competitively regulated by ABCA1 and SR-BI.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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