Thermo Fisher Scientific PSMA7 Monoclonal Antibody (OTI8B11), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

PSMA7 is a component of the 20S core proteasome complex, responsible for proteolytic degradation of intracellular proteins.
It forms the 26S proteasome when associated with two 19S regulatory particles, enabling ATP-dependent degradation of ubiquitinated proteins.
The 20S proteasome also mediates ubiquitin-independent protein degradation, essential for spermatogenesis and generation of MHC class I-presented peptides.
PSMA7 inhibits HIF-1A transactivation under normoxic and hypoxic conditions, aids HIF-1A degradation via EMAP2 interaction, and plays a role in hepatitis C virus translation.
It also mediates nuclear translocation of the androgen receptor, enhancing androgen-mediated transactivation.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.