Thermo Fisher Scientific PSMA7 Monoclonal Antibody (OTI4A9), TrueMAB

Applications

• Western Blot (WB): 1:500–1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

PSMA7 is a component of the 20S core proteasome complex, which mediates proteolytic degradation of intracellular proteins.
This complex associates with regulatory particles to form the 26S proteasome, enabling ATP-dependent degradation of ubiquitinated proteins and maintaining protein homeostasis.
The 20S proteasome also functions independently in ubiquitin-independent degradation, essential for processes such as spermatogenesis and MHC class I antigen peptide generation.
PSMA7 inhibits HIF-1A transactivation under normoxic and hypoxic conditions and contributes to HIF-1A degradation via EMAP2 interaction.
It also plays roles in hepatitis C virus translation and androgen receptor nuclear translocation, enhancing androgen-mediated transcriptional activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.