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Thermo Fisher Scientific Phospho-CDC34 (Ser71) Polyclonal Antibody
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CDC34 단백질의 Ser71 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며, 인간, 마우스, 랫트 시료에 반응. 고순도 정제 및 안정적 액상 형태로 제공되어 연구용으로 적합.
- 판매단위
- pk
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마지막 업데이트 2025. 08. 03. 오후 01:01
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Thermo Fisher Scientific PA5105365 Phospho-CDC34 (Ser71) Polyclonal Antibody 100 ul pk판매 단위 pk ·
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627,600원VAT 포함 690,360원
Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-CDC34 (Ser71) Polyclonal Antibody
Thermo Fisher Scientific Phospho-CDC34 (Ser71) Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDC34 (Accession P49427), corresponding to amino acid residues around phosphorylated Ser71 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816793 |
Product Specific Information
Antibody detects endogenous levels of CDC34 only when phosphorylated at Ser71.
Target Information
CDC34 accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.
- Catalyzes Lys-48–linked polyubiquitination in vitro.
- Cooperates with E2 UBCH5C and SCF (FBXW11) E3 ligase complex for polyubiquitination of NFKBIA, leading to proteasomal degradation.
- Performs ubiquitin chain elongation from UBE2D3-primed NFKBIA-linked ubiquitin.
- Regulates cell proliferation via SCF (SKP2) E3 ligase complex through ubiquitination and degradation of MYBL2 and KIP1.
- Involved in degradation of CREM isoform ICERIIgamma and ATF15, abrogating their repression of cAMP-induced transcription.
- Regulates G2/M phase by targeting WEE1 kinase for ubiquitination and degradation.
- Also involved in degradation of beta-catenin.
- Target of human herpes virus 1 protein ICP0, leading to ICP0-dependent interaction with proteasomes.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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