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Thermo Fisher Scientific Phospho-CDC34 (Ser71) Polyclonal Antibody
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Thermo Fisher Scientific Phospho-CDC34 (Ser71) Polyclonal Antibody

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CDC34 단백질의 Ser71 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며, 인간, 마우스, 랫트 시료에 반응. 고순도 정제 및 안정적 액상 형태로 제공되어 연구용으로 적합.

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마지막 업데이트 2025. 08. 03. 오후 01:01
Thermo Fisher Scientific PA5105365 Phospho-CDC34 (Ser71) Polyclonal Antibody 100 ul pk판매 단위 pk ·
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Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-CDC34 (Ser71) Polyclonal Antibody

Thermo Fisher Scientific Phospho-CDC34 (Ser71) Polyclonal Antibody

Applications

  • Western Blot (WB): 1:500–1:2,000

Product Specifications

항목 내용
Species Reactivity Human, Mouse, Rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen A synthesized peptide derived from human CDC34 (Accession P49427), corresponding to amino acid residues around phosphorylated Ser71
Conjugate Unconjugated
Form Liquid
Concentration 1 mg/mL
Purification Sequential chromatography
Storage Buffer PBS, pH 7.4, with 50% glycerol
Contains 0.02% sodium azide
Storage Conditions -20°C
Shipping Conditions Wet ice
RRID AB_2816793

Product Specific Information

Antibody detects endogenous levels of CDC34 only when phosphorylated at Ser71.

Target Information

CDC34 accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.

  • Catalyzes Lys-48–linked polyubiquitination in vitro.
  • Cooperates with E2 UBCH5C and SCF (FBXW11) E3 ligase complex for polyubiquitination of NFKBIA, leading to proteasomal degradation.
  • Performs ubiquitin chain elongation from UBE2D3-primed NFKBIA-linked ubiquitin.
  • Regulates cell proliferation via SCF (SKP2) E3 ligase complex through ubiquitination and degradation of MYBL2 and KIP1.
  • Involved in degradation of CREM isoform ICERIIgamma and ATF15, abrogating their repression of cAMP-induced transcription.
  • Regulates G2/M phase by targeting WEE1 kinase for ubiquitination and degradation.
  • Also involved in degradation of beta-catenin.
  • Target of human herpes virus 1 protein ICP0, leading to ICP0-dependent interaction with proteasomes.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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