Thermo Fisher Scientific ADAM10 Polyclonal Antibody
ADAM10 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot 및 Immunocytochemistry에 적합하며, Human 반응성으로 확인되었습니다. 고순도 Protein A 정제, 액상 형태, 장기 보관 시 -20°C에서 안정적입니다.
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Thermo Fisher Scientific ADAM10 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 732–748 of Human ADAM10. This sequence is identical to bovine and rat origins, differing from mouse ADAM10 by one amino acid. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2222926 |
Product Specific Information
- Recommended positive controls: K-562 Cell Slide (GTX25535), Jurkat Cell Lysate (GTX27899)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
Proinflammatory cytokine TNF-α contributes to various inflammatory responses and programmed cell death. The Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including T-cell lymphoma.
TNF-α, Notch, and its ligand Delta are membrane-bound molecules cleaved by proteases to release mature proteins or functional receptors.
ADAM10, a metalloprotease-disintegrin in the mammalian ADAM family, was identified to cleave TNF-α, Notch, and Delta.
Human, mouse, and bovine ADAM10 genes have been cloned and designated ADAM10, KUZ (kuzbanian), and MADM, respectively. ADAM10 mRNA is expressed in various human and bovine tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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