Thermo Fisher Scientific FGF23 (Fibroblast Growth Factor 23) Monoclonal Antibody (FGF23/4171)
인간 FGF23 단백질을 인식하는 단클론 항체로, IHC(P) 및 Peptide Array에 사용 가능. 단백질 A/G 정제, 200 µg/mL 농도의 액상 포맷. 인간 신장 조직에서 양성 대조로 사용 가능하며, 4°C에서 안정적으로 보관됨.
- 카탈로그번호
- 8074-MSM11-P1
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- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FGF23/4171 |
| Immunogen | Recombinant fragment (around aa25–251) of human FGF23 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Stability: Antibody is stable for 24 months
- Positive Control: Human kidney tissue
- Cellular Localization: Secreted (extracellular)
Specificity Comments:
Fibroblast growth factors (FGFs) are a family of proteins that stimulate proliferation of mesenchymal, epithelial, and neuroectodermal cells. Members include FGF-1 through FGF-23, sharing 30–55% amino acid sequence identity. FGFs bind to specific tyrosine kinase receptors such as FGFR-1 (Flg), FGFR-2 (Bek), TKF, and FGFR-3, mediating cell growth and differentiation.
Target Information
The FGF23 gene encodes a member of the fibroblast growth factor family involved in diverse biological processes such as embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion.
FGF23 inhibits renal tubular phosphate transport and mutations in this gene are associated with autosomal dominant hypophosphatemic rickets and familial tumoral calcinosis. Overexpression is linked to oncogenic hypophosphatemic osteomalacia.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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