Thermo Fisher Scientific IGF2R Recombinant Rabbit Monoclonal Antibody (SR45-09)
IGF2R 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용에 적합합니다. 높은 특이성과 일관된 로트 간 품질을 제공하며, 동물 유래 성분이 없는 포뮬레이션으로 연구 재현성을 향상시킵니다.
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Thermo Fisher Scientific IGF2R Recombinant Rabbit Monoclonal Antibody (SR45-09)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:250 |
| Flow Cytometry (Flow) | 1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SR45-09 |
| Immunogen | Synthetic peptide within Human M6PR aa 2,442–2,491 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809310 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are transported within the cell through two interconnected cycles involving the cation-independent mannose 6-phosphate receptor (CI-MPR, ~300 kDa).
The biosynthetic cycle delivers newly synthesized lysosomal enzymes from the trans-Golgi network to late endosomes or lysosomes, while the endocytic cycle moves extracellular lysosomal enzymes from the plasma membrane to early endosomes.
MPRs cycle between these compartments approximately every 3 hours, with the majority residing in late endosomes, fewer in the trans-Golgi network, and about 10% at the cell surface.
CI-MPR also binds IGF-II via a separate binding site, enabling simultaneous binding of man6P and IGF-II. A soluble truncated form (~240 kDa) of the receptor circulates in serum and retains ligand-binding capability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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