Thermo Fisher Scientific AOX1 Recombinant Rabbit Monoclonal Antibody (PSH0-17)
AOX1 단백질을 인식하는 토끼 단클론 항체로 Western blot, IHC, Flow Cytometry에 사용 가능. 인간, 마우스, 랫트 반응성. HEK293 세포에서 발현된 Recombinant IgG 형식. 단백질 A 정제, PBS/BSA/glycerol buffer. 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PSH0-17 |
| Immunogen | Synthetic peptide within human AOX1 aa 1301–1338/1338 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3094138 |
Product Specific Information
- Positive control: Rat liver tissue lysates, rat liver tissue, rat adrenal gland tissue, human kidney tissue, mouse testis tissue, Hela
- Predicted band size: 148 kDa
- Subcellular Location: Cytoplasm
Target Information
AOX1 (Aldehyde oxidase 1) is a 1338 amino acid cytoplasmic protein that catalyzes the oxidation of various aldehydes, producing hydrogen peroxide. Under certain conditions, AOX1 can catalyze the formation of the superoxide free radical. Defects in oxygen radical metabolism have been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by motor neuron death. AOX1 is highly expressed in the ventral horn of the spinal cord, and the AOX1 gene is located in a chromosomal region implicated in ALS2, suggesting its potential role as a candidate gene for ALS2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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