Thermo Fisher Scientific c-Met Recombinant Rabbit Monoclonal Antibody (PSH0-19)
인간 c-Met 단백질을 인식하는 재조합 토끼 단클론 항체로, WB, IHC, Flow Cytometry에 적합합니다. HEK293 발현 시스템 기반으로 제조되었으며, 높은 특이성과 재현성을 제공합니다. 암 연구 및 신호전달 경로 분석에 활용 가능합니다.
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Thermo Fisher Scientific c-Met Recombinant Rabbit Monoclonal Antibody (PSH0-19)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:800 |
| Flow Cytometry (Flow) | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PSH0-19 |
| Immunogen | Synthetic peptide within human Met aa 1341–1390 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3092890 |
Product Specific Information
- Positive control: A549, HepG2, HT-29, HeLa, LO2 cell lysates, human lung adenocarcinoma tissue
- Predicted band size: 156 kDa
- Subcellular Location: Membrane; Secreted
Target Information
MET (c-Met) is a receptor-like tyrosine kinase associated with various human malignancies. Upon ligand activation, MET interacts with PI3K subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, triggering signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
MET plays critical roles in embryonic development (gastrulation, muscle and neuron development, angiogenesis, kidney formation) and in adult processes such as wound healing, organ regeneration, and tissue remodeling.
Dysregulation of MET is linked to cancers including gastric, renal, and breast cancers, making it a key target for cancer research and diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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