Thermo Fisher Scientific IL-1 beta Monoclonal Antibody (2805)
IL-1 beta 단백질을 검출 및 중화하는 Mouse IgG1 단일클론 항체. Western blot, ELISA, ICC/IF 등 다양한 응용에 적합. 인간 및 마우스 반응성. 단백질 A/G 정제, 동결건조 형태로 제공. 염증 관련 연구에 활용 가능.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL-1 beta Monoclonal Antibody (2805)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 8–25 µg/mL | - |
| ELISA (Detection) | 0.1–0.4 µg/mL | - |
| ELISA (Capture) | 2–8 µg/mL | - |
| Neutralization (Neu) | 0.05–0.2 µg/mL | - |
| Functional Assay | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2805 |
| Immunogen | E. coli-derived recombinant human IL-1 beta/IL-1F2 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609796 |
Product Specific Information
- In sandwich ELISAs, this antibody shows less than 4% cross-reactivity with recombinant rat IL-1 beta and less than 0.1% with recombinant porcine IL-1 beta, rhIL-1 alpha, rpIL-1 alpha, rrIL-1 alpha, rmIL-1 alpha, and rmIL-1 beta.
- Reconstitute at 0.5 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of antibody by the LAL method.
Target Information
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol and is cleaved into an active 17 kDa form upon inflammasome activation.
IL-1 beta lacks a signal peptide and is secreted via a non-classical pathway alongside caspase-1. It signals through IL-1RI and IL-1RII receptors, shared with IL-1 alpha, and its activity is regulated by IL-1 Receptor Antagonist (IL-1RA).
Elevated IL-1 beta levels are associated with chronic inflammatory conditions, and neutralizing antibodies may have potential therapeutic value.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.