
Thermo Fisher Scientific Protein C Monoclonal Antibody (5072)
인간 Protein C를 인식하는 마우스 모노클로날 항체로 ELISA 및 Western blot에 사용 가능. 비결합형 액상 형태이며 SDS-PAGE로 정제됨. 고농도(4.9 mg/mL)로 안정적이며 -20°C에서 보관. 연구용으로 혈액 응고 관련 단백질 분석에 적합.
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Thermo Fisher Scientific Protein C Monoclonal Antibody (Clone 5072)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| ELISA | 5–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5072 |
| Immunogen | Human protein C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 4.9 mg/mL |
| Purification | SDS-PAGE |
| Storage Buffer | 50% water with 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1086884 |
Product Specific Information
MA1-43016 detects Protein C in human samples.
MA1-43016 has successfully been used in ELISA applications.
MA1-43016 was derived from human protein C.
Target Information
Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex.
Activated Protein C contains a serine protease domain and functions in degradation of activated coagulation factors V and VIII.
Protein C is produced in the liver and composed of two polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor, and the active enzyme (55 kDa) cleaves factor Va and VIIIa, thus inhibiting blood coagulation.
Normal concentrations in human plasma are approximately 1–3 ng/mL for the active enzyme and ~3 µg/mL for the proenzyme.
Mutations in the Protein C gene are associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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