Thermo Fisher Scientific LIMK1 Polyclonal Antibody
Rabbit polyclonal antibody against human LIMK1 for WB and IP applications. Targets residues 250–300 of LIM domain kinase 1. Supplied unconjugated, liquid form, 1 mg/mL concentration. Ideal for research use in studies of actin cytoskeletal regulation an...
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Applications
- Western Blot (WB): Assay-dependent
- Immunoprecipitation (IP): 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 250 and 300 of human LIM domain kinase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
LIMK1 is a serine/threonine kinase involved in regulation of actin cytoskeletal changes via phosphorylation of cofilin. It also plays a role in brain development. LIM domains are highly conserved cysteine-rich structures containing two zinc fingers. While zinc fingers often bind DNA or RNA, the LIM motif likely mediates protein–protein interactions. LIM kinase-1 and LIM kinase-2 form a subfamily characterized by two N-terminal LIM motifs and a C-terminal kinase domain. LIMK1 may participate in intracellular signaling pathways and has been associated with cognitive impairment in Williams syndrome due to hemizygosity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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