Thermo Fisher Scientific Lamin B2 Monoclonal Antibody (D5-C2)
Lamin B2 단백질을 인식하는 Mouse monoclonal 항체로, WB, IHC, ICC/IF 분석에 적합합니다. Human, Mouse, Rat, Zebrafish에 반응하며, Protein A로 정제된 고순도 항체입니다. 세포 핵막 연구 및 구조 단백질 분석에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat, Zebrafish |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | D5-C2 |
| Immunogen | Synthetic peptide within Human LMNB2 aa 571–620/620 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931077 |
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type lamins and B-type lamins.
A-type lamins include lamin A, lamin C, and lamin Adel10, which arise from the same gene by alternative splicing.
B-type lamins include lamin B1 and lamin B2, arising from two distinct genes.
Mutations in A-type lamins are associated with rare but dominant genetic disorders such as Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease, and Dunnigan-type familial partial lipodystrophy.
A-type lamins are expressed during cell differentiation and interact with chromatin, suggesting a role in regulating differential gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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