Thermo Fisher Scientific FAM111A Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Immunogen sequence:
RSRKHSVNEK CNMKIEHYFS PVSKEQQNNC STSLMRMESR GDPRATTNTQ AQRFHSPKKN PEDQTMPQNR TIYVTLKVNH RRNQDMKL

• Highest antigen sequence identity to orthologs:
  • Mouse: 45%
  • Rat: 47%

Target Information

Chromosome 11 contains approximately 135 million base pairs and about 1,400 genes, representing around 4% of human genomic DNA. It is known as a gene- and disease-association dense chromosome.
The Atm gene on chromosome 11 regulates cell cycle arrest and apoptosis following double-strand DNA breaks; mutations cause ataxia telangiectasia.
Mutations in the HBB gene cause blood disorders such as sickle cell anemia and β-thalassemia.
WT1 gene mutations are associated with Wilms’ tumor, WAGR syndrome, and Denys-Drash syndrome.
Other disorders linked to chromosome 11 defects include Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema, and Smith-Lemli-Opitz syndrome.
The FAM111A gene product has been provisionally designated FAM111A pending further characterization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.