Thermo Fisher Scientific SLC22A18 Polyclonal Antibody
SLC22A18 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 최적화된 항체로, 인간 ORCTL-2 C-말단 펩타이드 유래 면역원 사용. 액상 형태, 1 mg/mL 농도, -20°C 보관.
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Applications
- Western Blot (WB): Tested dilution 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the C-terminal region of human ORCTL-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555355 |
Target Information
ORCTL2 (organic cation transporter-like protein 2), also known as HET, ITM, BWR1A, IMPT1, TSSC5, BWSCR1A, SLC22A1L, p45-BWR1A or SLC22A18, is a 424 amino acid multi-pass membrane protein localized at the apical membrane surface of renal proximal tubules.
It is highly expressed in kidney, liver, colon, and fetal renal proximal tubules, with lower expression in heart, brain, and lung.
Belonging to the major facilitator superfamily, ORCTL2 may act as a transporter of organic cations via a proton efflux antiport mechanism and may also play a role in the transport of chloroquine and quinidine-related compounds in kidney.
Defects in ORCTL2 are associated with breast and lung cancer and are the cause of rhabdomyosarcoma type 1, a malignant tumor derived from striated muscle.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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