Thermo Fisher Scientific Phospho-CENTB1 (Ser554) Polyclonal Antibody
인간 Centaurin-beta 1의 Ser554 인산화 부위에 특이적인 Rabbit Polyclonal 항체. IHC(P)에서 1:50–1:100 희석으로 사용 가능. 비결합(Unconjugated) 상태의 액상 항체로 -20°C 보관. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human Centaurin-beta 1 around the phosphorylation site of Ser554 (P-G-SP-L-R) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2555347 |
Target Information
ACAP1, also known as Centaurin-beta-1 (CENTB1), is a 740 amino acid transport carrier belonging to the Centaurin family. It contains three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain that binds to phospholipids.
ACAP1 functions as a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) and is required for clathrin-dependent export of proteins from recycling endosomes to the trans-Golgi network and cell surface.
It mediates CENTB1 binding to phosphatidylinositol 3,5-bisphosphate (PIP2) or phosphatidylinositol 3,4,5-trisphosphate (PIP3) containing membranes.
Along with ACAP2, ACAP1 is recruited to PDGF-induced dorsal membrane ruffles in NIH 3T3 mouse fibroblasts, and overexpression inhibits ruffle formation.
It is widely expressed in most tissues, with high expression in lung and spleen and low expression in heart, kidney, liver, and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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