Thermo Fisher Scientific PCDHA12 Polyclonal Antibody

Thermo Fisher Scientific PCDHA12 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:3,000
• Immunocytochemistry (ICC/IF): 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: U87-MG, MCF-7
• Predicted reactivity: Chimpanzee (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.
The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences.
The tandem array of 15 N-terminal exons (variable exons) are followed by downstream C-terminal exons (constant exons), which are shared by all genes in the cluster.
These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that likely play a critical role in the establishment and function of specific cell-cell connections in the brain.
Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

Usage

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-31545_PCDHA12_Q9UN75-1_Rabbit.svg, PA5-31545_PCDHA12_Q9UN75-1_Rabbit_PDP.jpeg)