Thermo Fisher Scientific Phospho-CHK2 (Ser33, Ser35) Polyclonal Antibody
CHK2 단백질의 Ser33/Ser35 인산화 상태를 검출하는 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며 인간 및 비인간 영장류에 반응. 항원 친화 크로마토그래피로 정제된 액상 제품으로, DNA 손상 반응 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer33/35 of human Chk2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10984514 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with Chk2 phosphorylated at other sites.
Target Information
CHEK2 (CHK2) is a serine/threonine kinase involved in the DNA damage checkpoint pathway. Mutations in CHK2 are associated with various cancers. CHK2 activation by DNA damage leads to phosphorylation of several cell cycle regulators, including tumor suppressor proteins. It can phosphorylate BRCA1, aiding in DNA damage recovery. CHK2 mutations are linked to Li-Fraumeni syndrome and predisposition to sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송 정보
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