Thermo Fisher Scientific Phospho-c-Abl (Thr735) Polyclonal Antibody
인간 c-Abl 단백질의 Thr735 인산화 부위를 인식하는 폴리클로날 항체. Western blot에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제됨. 보존제가 없고 -20°C에서 보관. 관련 단백질과 교차 반응 없음.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pThr735 of human c-Abl |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10978154 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other related proteins.
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in:
- Cell differentiation
- Cell division
- Cell adhesion
- Stress response
Activity of c-Abl protein is negatively regulated by its SH3 domain; deletion of this domain turns c-Abl into an oncogene.
The DNA-binding activity of ABL1 is regulated by CDC2-mediated phosphorylation, suggesting a role in the cell cycle.
In chronic myelogenous leukemia (CML) and some acute lymphoblastic leukemias (ALL), the c-Abl proto-oncogene undergoes a (9;22) translocation forming the Philadelphia chromosome, fusing c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22.
The c-Abl oncogene was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV).
c-Abl may regulate DNA repair by activating the proapoptotic pathway when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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