Thermo Fisher Scientific Nicastrin Polyclonal Antibody
Nicastrin 단백질을 표적으로 하는 Rabbit Polyclonal Antibody로, Western blot에 적합합니다. 인간, 마우스, 비인간 영장류, 랫트 반응성을 가지며 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 -20°C 보관하며, 연구용으로만 사용됩니다.
- 카탈로그번호
- PA517735
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the carboxy-terminus of human Nicastrin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 183 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981453 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
NCSTN (Nicastrin) encodes a type I transmembrane glycoprotein that is a component of the gamma-secretase complex. This protein cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. It may act as a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein produces amyloid beta peptide, a hallmark of Alzheimer’s disease. Mutations in this gene are associated with familial acne inversa. A pseudogene is located on chromosome 21.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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