Thermo Fisher Scientific AFP Monoclonal Antibody (OTI2F11), TrueMAB
인간 AFP 단백질을 인식하는 마우스 단클론 항체로 Western blot, IHC, ICC/IF에 적합. 고순도 친화 크로마토그래피 정제, PBS/BSA/glycerol 버퍼에 저장. 연구용으로 간암 등 AFP 관련 질환 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 19–397 of human AFP produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
AFP (Alpha Fetoprotein) is a major plasma protein produced by the yolk sac, intestinal tract, and liver during fetal life. AFP expression in adults is often associated with hepatoma or teratoma. Hereditary persistence of AFP may also occur in individuals without apparent pathology. AFP is considered the fetal counterpart of serum albumin, and AFP and albumin genes are located in tandem on chromosome 4.
AFP exists in monomeric, dimeric, and trimeric forms, and can bind copper, nickel ions, fatty acids, and bilirubin. AFP levels in amniotic fluid are used to assess renal protein loss and screen for spina bifida and anencephaly. Elevated serum AFP is observed in hepatocellular carcinoma (HCC), teratoblastoma, colorectal cancer, pancreatic cancer, and germ cell neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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