Thermo Fisher Scientific ADAR1 Recombinant Rabbit Monoclonal Antibody (ARC0602)

Thermo Fisher Scientific ADAR1 Recombinant Rabbit Monoclonal Antibody (ARC0602)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
STQAWNQHSG VVRPDGHSQG APNSDPSLEP EDRNSTSVSE DLLEPFIAVS AQAWNQHSGV VRPDSHSQGS PNSDPGLEPE DSNSTSALED PLEFLDMAEI K

Target Information

Adenosine Deaminase RNA Specific (ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing. This process can affect gene expression and protein function through mechanisms including:

• Alteration of codons and amino acid sequences in mRNA translation
• Modification of splice site recognition in pre-mRNA splicing
• Changes in RNA stability and nuclease recognition
• Impact on genetic stability in RNA virus genomes
• Influence on microRNA production and protein-RNA interactions

ADAR can edit both viral and cellular RNAs, either at multiple sites (hyper-editing) or specific sites (site-specific editing). Known cellular substrates include:

• BLCAP (bladder cancer-associated protein)
• GRIA2 (glutamate receptor)
• HTR2C (serotonin receptor)
• GABRA3 (GABA receptor)

Site-specific editing of these transcripts leads to amino acid substitutions that alter protein function. Viral RNA substrates include HCV, VSV, MV, HDV, and HIV-1. ADAR1 exhibits both proviral and antiviral effects depending on the virus and mechanism (editing-dependent or editing-independent). It modulates viral replication and host antiviral responses through RNA editing and suppression of EIF2AK2/PKR activation.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.

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