Thermo Fisher Scientific ADAR1 Recombinant Rabbit Monoclonal Antibody (ARC0602)
ADAR1 단백질을 표적하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체. Western blot, ICC/IF, ELISA에 사용 가능. 높은 특이성과 재현성을 제공하며, 연구용으로 적합. HEK293 세포에서 발현된 정제 항체로 안정적인 PBS 기반 용액 형태로 제공.
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Thermo Fisher Scientific ADAR1 Recombinant Rabbit Monoclonal Antibody (ARC0602)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:6,000 |
| Immunocytochemistry (ICC/IF) | 1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0602 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 200–300 of human ADAR1 (P55265) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849017 |
Product Specific Information
Immunogen sequence:
STQAWNQHSG VVRPDGHSQG APNSDPSLEP EDRNSTSVSE DLLEPFIAVS AQAWNQHSGV VRPDSHSQGS PNSDPGLEPE DSNSTSALED PLEFLDMAEI K
Target Information
Adenosine Deaminase RNA Specific (ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA), referred to as A-to-I RNA editing. This process can affect gene expression and protein function through mechanisms including:
- Alteration of codons and amino acid sequences in mRNA translation
- Modification of splice site recognition in pre-mRNA splicing
- Changes in RNA stability and nuclease recognition
- Impact on genetic stability in RNA virus genomes
- Influence on microRNA production and protein-RNA interactions
ADAR can edit both viral and cellular RNAs, either at multiple sites (hyper-editing) or specific sites (site-specific editing). Known cellular substrates include:
- BLCAP (bladder cancer-associated protein)
- GRIA2 (glutamate receptor)
- HTR2C (serotonin receptor)
- GABRA3 (GABA receptor)
Site-specific editing of these transcripts leads to amino acid substitutions that alter protein function. Viral RNA substrates include HCV, VSV, MV, HDV, and HIV-1. ADAR1 exhibits both proviral and antiviral effects depending on the virus and mechanism (editing-dependent or editing-independent). It modulates viral replication and host antiviral responses through RNA editing and suppression of EIF2AK2/PKR activation.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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