Thermo Fisher Scientific N4BP2L2 Monoclonal Antibody (OTI6A9), TrueMAB

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:150 dilution tested

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583-amino acid nuclear protein potentially involved in transcriptional regulation.
N4BP2L2 is phosphorylated on Ser199 in response to DNA damage, likely by ATM or ATR. It is primarily expressed in bone marrow and is significantly down-regulated after exposure to arsenic compounds, preceding neutropenia.
PFAAP5 interacts with Gfi-1 and Neutrophil Elastase, both implicated in neutropenia disorders. Defects in the ELA2 gene (encoding Neutrophil Elastase) cause cyclic haematopoiesis, leading to reduced neutrophil counts and increased susceptibility to opportunistic infections.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.