Thermo Fisher Scientific N4BP2L2 Monoclonal Antibody (OTI1E2), TrueMAB
인간 N4BP2L2 단백질을 인식하는 마우스 단클론 항체로, Western blot에 최적화되어 있습니다. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도로 사용 가능합니다. 연구용으로만 사용되며, 보존제 무첨가 PBS 버퍼에 포함되어 있습니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E2 |
| Immunogen | Full length human recombinant protein of human N4BP2L2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein potentially involved in transcriptional regulation.
N4BP2L2 is phosphorylated on Ser199 in response to DNA damage, likely by ATM or ATR. It is primarily expressed in bone marrow and is significantly down-regulated upon exposure to arsenic compounds, preceding neutropenia.
PFAAP5 interacts with Gfi-1 and Neutrophil Elastase, proteins implicated in neutropenia disorders. Defects in the gene encoding Neutrophil Elastase (ELA2) cause cyclic haematopoiesis, leading to reduced neutrophil counts and increased susceptibility to opportunistic infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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