Thermo Fisher Scientific ATM Polyclonal Antibody
ATM 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, ICC/IF, ELISA에 적합. 인간 및 랫트 반응성. 고순도 Affinity Chromatography 정제, 액상 형태로 안정적이며 DNA 손상 복구 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 2320–2566 of ATM (NP_0000423) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.71 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806135 |
Product Specific Information
Immunogen sequence:
DASCAANNPS LKLTYTECLR VCGNWLAETC LENPAVIMQT YLEKAVEVAG NYDGESSDEL RNGKMKAFLS LARFSDTQYQ RIENYMKSSE FENKQALLKR AKEEVGLLRE HKIQTNRYTV KVQRELELDE LALRALKEDR KRFLCKAVEN YINCLLSGEE HDMWVFRLCS LWLENSGVSE VNGMMKRDGM KIPTYKFLPL MYQLAARMGT KMMGGLGFHE VLNNLISRIS MDHPHHTLFI ILALANA
Positive Samples: Cellular Location: Cytoplasmic vesicle, Nucleus
Target Information
Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein within the phosphoinositide 3-kinase (PI3K) superfamily. Unlike typical PI3Ks, ATM phosphorylates proteins rather than lipids, targeting cell-cycle regulators such as P53, Mdm2, BRCA1, and SMC1.
ATM plays a key role in repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens. Its C-terminal region shares homology with catalytic domains of PI3 kinases.
ATM becomes autophosphorylated and activated upon exposure to ionizing radiation, initiating kinase cascades that regulate cell cycle, apoptosis, and DNA damage repair.
ATM is also linked to apoptosis pathways involving Nbs1 and Chk2 in the E2F1 signaling axis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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