Thermo Fisher Scientific ATM Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Immunogen sequence:
DASCAANNPS LKLTYTECLR VCGNWLAETC LENPAVIMQT YLEKAVEVAG NYDGESSDEL RNGKMKAFLS LARFSDTQYQ RIENYMKSSE FENKQALLKR AKEEVGLLRE HKIQTNRYTV KVQRELELDE LALRALKEDR KRFLCKAVEN YINCLLSGEE HDMWVFRLCS LWLENSGVSE VNGMMKRDGM KIPTYKFLPL MYQLAARMGT KMMGGLGFHE VLNNLISRIS MDHPHHTLFI ILALANA

Positive Samples: Cellular Location: Cytoplasmic vesicle, Nucleus

Target Information

Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family. Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein within the phosphoinositide 3-kinase (PI3K) superfamily. Unlike typical PI3Ks, ATM phosphorylates proteins rather than lipids, targeting cell-cycle regulators such as P53, Mdm2, BRCA1, and SMC1.
ATM plays a key role in repairing double-stranded DNA breaks caused by ionizing radiation and other mutagens. Its C-terminal region shares homology with catalytic domains of PI3 kinases.
ATM becomes autophosphorylated and activated upon exposure to ionizing radiation, initiating kinase cascades that regulate cell cycle, apoptosis, and DNA damage repair.
ATM is also linked to apoptosis pathways involving Nbs1 and Chk2 in the E2F1 signaling axis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.