Thermo Fisher Scientific FceR1 alpha Monoclonal Antibody (AER-37 (CRA1)), APC, eBioscience

Applications and Tested Dilution

• Application: Flow Cytometry (Flow)
• Tested Dilution: 5 µL (0.125 µg)/test
• Publications: View 14 publications

Product Specifications

Available Formats

• Unconjugated
• Biotin
• Brilliant Violet 786
• eFluor 450
• FITC
• Functional Grade
• NovaFluor Blue 610-70S
• NovaFluor Blue 660-120S
• NovaFluor Yellow 570
• NovaFluor Yellow 610
• NovaFluor Yellow 660
• PE
• PE-Cyanine7
• PE-eFluor 610
• PerCP-eFluor 710
• Super Bright 436
• Super Bright 600
• Super Bright 780
• Request custom conjugation

Product Specific Information

The AER-37 monoclonal antibody reacts with the Fc epsilon RI alpha subunit, an IgE-binding subunit lacking signal-transducing ability. FcεRIα is expressed on mast and basophil cells and is upregulated by the presence of IgE. It forms a tetrameric complex with one beta and two gamma subunits, which contain ITAM motifs responsible for signal transduction. The FcεRI complex plays a key role in IgE-mediated allergic reactions.

• Applications Reported: Flow cytometric analysis
• Applications Tested: Pre-titrated and validated for flow cytometry using peripheral blood cells
• Recommended Usage: 5 µL (0.125 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test)
• Excitation: 633–647 nm
• Emission: 660 nm
• Laser: Red Laser
• Filtration: 0.2 µm post-manufacturing filtered

Target Information

FceR1 (Fc epsilonR1 alpha) is a subunit of the high-affinity receptor for IgE. It forms a tetrameric complex (αβγ₂) where the β and γ subunits mediate signal transduction. This receptor is central to allergic responses by triggering histamine and mediator release upon allergen-IgE binding. FcεRI couples allergen recognition to mast cell activation, leading to inflammatory responses characteristic of allergic disorders such as hay fever and asthma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지