Thermo Fisher Scientific APP Monoclonal Antibody (OTI7B8), TrueMAB
APP 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, IHC, ICC, Flow Cytometry에 사용 가능. Human 시료에 반응하며, Lyophilized 형태로 제공. Alzheimer’s disease 연구 등 신경 관련 단백질 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7B8 |
| Immunogen | Full length human recombinant protein of human APP produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor mediating axonal transport of beta-secretase and presenilin 1.
APP is important for neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein existing in several isoforms due to alternative splicing.
Proteolytic cleavage by beta- and gamma-secretases generates beta amyloid, the primary component of senile plaques — a hallmark of Alzheimer’s disease.
Abnormal APP processing is also implicated in Down’s syndrome, early onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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