Thermo Fisher Scientific IL18BP Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Positive controls: K562 cell lysates, LOVO, rat spleen tissue, human spleen tissue, mouse spleen tissue, A549.

Target Information

Interleukin-18 binding protein (IL-18BP) is a constitutively secreted glycoprotein that acts as a natural antagonist for interleukin-18 (IL-18) by preventing interaction between IL-18 and its receptors. Through this binding, IL-18BP neutralizes the proinflammatory role of IL-18 in cell-mediated immune responses, resulting in reduced IFN-gamma production by T helper type I cells and inhibition of allospecific cytotoxic T lymphocyte (CTL) activity through augmented natural killer (NK) cell cytotoxicity.

As an inhibitor of IL-18 and an essential component of skin homeostasis, IL-18BP has been linked to diseases such as eczema, asthma, and Crohn’s disease. Upregulation of IL-18BP by keratinocytes expressing HPV E7 oncoprotein decreases IL-18-induced IFN-gamma production and IL-18-mediated T cell activation. Elevated IL-18 and IL-18BP levels, along with proinflammatory cytokines IFN-gamma, TNF-alpha, IL-1beta, and IL-8, are associated with chronic inflammation in macrophages and intestinal tissues of Crohn’s disease patients.

IL-18BP belongs to the immunoglobulin-like class of receptors and contains a single immunoglobulin (Ig) domain. Two of the four identified human isoforms (b and d) contain incomplete domains with reduced binding affinity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.