Thermo Fisher Scientific TGM2 Polyclonal Antibody
TGM2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 고품질 항체.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Human Transglutaminase 2 (aa 317–520) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2901095 |
Product Specific Information
Positive Controls:
HUVEC cell lysate, mouse lung tissue lysate, HUVEC, Siha, rat uterus tissue, human lung cancer tissue, human placenta tissue, mouse heart tissue, Hela.
Target Information
Transglutaminase (TGase) catalyzes the crosslinking of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires Ca²⁺ binding for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal β-sandwich, catalytic core, and two C-terminal β-barrel domains.
tTGase may play roles in cell death, proliferation, differentiation, and receptor-mediated endocytosis. In Alzheimer’s disease, elevated tTGase activity leads to polymerization of proteins including Aβ peptide, β-amyloid precursor protein, and tau, forming neurofibrillary tangles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(해당 항원 구조 이미지: PA5-116463_TGM2_P21980-1_Rabbit.svg / PA5-116463_TGM2_P21980-1_Rabbit_PDP.jpeg)
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