Thermo Fisher Scientific Factor XIII A Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Positive controls: Human placenta tissue lysate, human liver tissue lysate, human placenta tissue, HeLa.

Target Information

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits act as plasma carrier molecules. Platelet factor XIII consists only of two A subunits, identical to those of plasma origin.

Upon cleavage of the activation peptide by thrombin and in the presence of calcium ions, plasma factor XIII dissociates its B subunits and yields the active enzyme, factor XIIIa. This enzyme acts as a transglutaminase to catalyze crosslinking between fibrin molecules, stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to fibrin alpha chains.

Factor XIII deficiency is classified into two categories:

• Type I deficiency: Lack of both A and B subunits
• Type II deficiency: Lack of the A subunit alone

These defects can lead to lifelong bleeding tendencies, defective wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.