Thermo Fisher Scientific MDM4 Monoclonal Antibody (OTI1E8), TrueMAB
MDM4 단백질을 인식하는 Mouse monoclonal antibody로 Western blot과 Immunocytochemistry에 적합. Human 시료 반응성, Lyophilized 형태로 제공되며, 재구성 후 약 1 mg/mL 농도. 연구용으로 p53 조절 연구에 유용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E8 |
| Immunogen | Full length human recombinant protein of human MDM4 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The MDM2 protein is the primary regulator of p53 protein stability. MDMX (also known as MDM4) is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 through distinct interactions with MDM2.
The MDMX gene is often amplified in malignant gliomas. ARF interacts with MDMX to sequester it within the nucleolus, increasing p53 transactivation. Expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation.
Like MDM2, MDMX also binds and stabilizes p73, leading to an increased half-life of p73.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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