Thermo Fisher Scientific NCR2 Monoclonal Antibody (OTI4B8), TrueMAB
인간 NCR2 단백질을 인식하는 마우스 단클론 항체로, WB 및 IHC(P) 분석에 적합합니다. TrueMAB 형식으로 고순도 정제된 액상 제품이며, 안정적인 PBS/BSA/glycerol 버퍼에 보존됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 44–190 of human NCR2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD336, also known as NKp44 or NCR2, is a 44 kDa transmembrane glycoprotein belonging to the natural cytotoxicity receptor (NCR) family. It contains an ITIM domain in its cytoplasmic tail and requires association with DAP12, an ITAM-containing transmembrane accessory protein, for NK cell activation.
Originally thought to be expressed only on IL-2–activated NK cells and some γδ T lymphocytes, CD336 is now known to be expressed on IL-3–stimulated plasmacytoid dendritic cells, αβ T cells in the small intestinal epithelium, and T cells in cord blood.
CD336 plays a role in the innate immune response of activated NK cells against viral infection and tumor cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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