Thermo Fisher Scientific TRMT12 Monoclonal Antibody (OTI5C9), TrueMAB
TRMT12 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI5C9). Western blot과 IHC(P)에서 검증됨. Human 시료에 반응하며, Affinity chromatography로 정제된 액상형 항체. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5C9 |
| Immunogen | Full length human recombinant protein of human TRMT12 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TYW2 (also known as TRM12) is an enzyme involved in the wybutosine-tRNA (Phe) biosynthesis pathway.
Wybutosine (yW) is a hypermodified guanosine at the 3′ position adjacent to the anticodon of phenylalanine tRNA, stabilizing codon–anticodon interactions during ribosomal decoding.
TYW2 participates in a multistep enzymatic process ensuring accurate translation and has been reported to be amplified in several breast cancer cell lines.
qPCR analysis of 30 breast tumors showed overexpression (>2-fold) of TYW2 mRNA in 26 cases, suggesting a potential role in breast cancer progression.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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