Thermo Fisher Scientific CD63 Monoclonal Antibody (OTI3G6), TrueMAB

Applications

Flow Cytometry (Flow)

• Tested Dilution: 1:50

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

CD63 (LAMP-3, lysosome-associated membrane protein-3) is a glycoprotein of the tetraspanin family found in late endosomes, lysosomes, and secretory vesicles.
It is also present on the plasma membrane following cell activation and is widely used as a basophil activation marker.

CD63 interacts with integrins, influencing phagocytosis and cell migration, and is involved in the regulation of H/K-ATPase trafficking and ROMK1 channels.
It functions as a T-cell costimulatory molecule and can serve as a prognostic marker in early-stage carcinomas.

CD63 is expressed on activated platelets, monocytes, macrophages, and weakly on granulocytes, B, and T cells.
It is identical to the melanoma-associated antigen ME491 and platelet antigen PTLGP40.
Dysfunction of CD63 is associated with melanoma and Hermansky-Pudlak Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.