Thermo Fisher Scientific Kidins220 (ARMS) Polyclonal Antibody
Rabbit polyclonal antibody targeting human Kidins220 (ARMS) protein. Validated for Western blot at 1:500–1:1,000 dilution. Supports research on neuronal survival, differentiation, and signaling. Supplied as liquid, 1 mg/mL concentration, for research u...
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Thermo Fisher Scientific Kidins220 (ARMS) Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Residues 1747–1762 [ASSESTGFGEERESIL] of the human 220kDa Kidins220 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Target Information
This gene encodes a transmembrane protein that is preferentially expressed in the nervous system, where it controls neuronal cell survival, differentiation into axons and dendrites, and synaptic plasticity.
The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways.
Aberrant expression of this gene is associated with various neuropsychiatric and neurodegenerative diseases, including Alzheimer’s disease. Naturally occurring mutations are linked to a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus, and obesity.
Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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