Thermo Fisher Scientific Patched tumor suppressor gene (PTCH) Polyclonal Antibody
Rabbit polyclonal antibody targeting the Patched (PTCH) tumor suppressor gene. Validated for Western blot applications. Recognizes mouse PTCH protein sequence (a.a. 269–279). Supplied as unconjugated liquid, 1 mg/mL concentration. Suitable for research...
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Thermo Fisher Scientific Patched Tumor Suppressor Gene (PTCH) Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KKINYQVDSWE (a.a. 269–279) of the mouse PTCH protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Target Information
The PTCH gene encodes a member of the patched gene family. The encoded protein acts as a receptor for sonic hedgehog, a secreted molecule involved in embryonic structure formation and tumorigenesis, as well as for desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations have been linked to basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, and holoprosencephaly.
Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full-length sequences and biological validity remain undetermined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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