Thermo Fisher Scientific Ki-67 (Proliferating Cell Marker) Monoclonal Antibody (MKI67/2465), Biotin
Ki-67 단백질을 표적하는 Biotin 결합 단일클론 항체로, 세포 증식 마커 연구에 적합합니다. IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 사용 가능하며, Human 시료 반응성을 가집니다. 4°C 보관, 동결 금지.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MKI67/2465 |
| Immunogen | Recombinant fragment (around aa 2293–2478) of human Ki-67 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Ki-67 is a nuclear protein expressed during various stages of the cell cycle, particularly during late G1, S, G2, and M phases. It contains a forkhead-associated (FHA) domain that enables association with euchromatin at the perichromosomal layer, centromeric heterochromatin, and the nucleolus.
Ki-67 shows a cell cycle-dependent distribution: perinucleolar expression at G1, nuclear matrix localization at G2, and chromosome association during M phase.
As a proliferation marker, Ki-67 is absent in G0 cells but increases from G1 through mitosis. It is widely used to determine the proliferative fraction in neoplasms, with prognostic value comparable to the tritiated thymidine-labeling index. A low Ki-67 index correlates with histologically low-grade tumors. It is routinely used as a neuronal marker for cell cycling and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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