Thermo Fisher Scientific mGluR5 (extracellular) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:400

Product Specifications

Product Specific Information

• Reconstitution: 25 µL, 50 µL, or 0.2 mL double distilled water (DDW), depending on sample size
• Ships as lyophilized powder at room temperature
• Upon arrival, store at -20°C
• Reconstituted solution can be stored at 4°C (protected from light) for up to 1 week
• For longer storage, aliquot and store at -20°C
• Avoid multiple freeze/thaw cycles
• Centrifuge all antibody preparations before use (10,000 × g, 5 min)

Target Information

GRK1 is a member of the guanine nucleotide protein-coupled receptor kinase (GRK) subfamily of the Serine/Threonine kinase family.
It phosphorylates rhodopsin and initiates its deactivation. G protein-mediated phosphorylation promotes arrestin binding, which removes the receptor from the G-protein and terminates the receptor signal chain.
GRK1 is farnesylated to promote membrane association and is inhibited by recoverin, a calcium-binding protein.
Dysfunction of GRK1 is associated with Oguchi Disease-2 and Hereditary Night Blindness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.