Thermo Fisher Scientific GRIK1 (GluK1) (extracellular) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW) depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For long-term storage, aliquot and store at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and play key roles in neurophysiological processes.
Grik1 (glutamate receptor 5) belongs to the kainate family of glutamate receptors, which form ligand-activated ion channels.
Grik1 is expressed in GABAergic interneurons of the hippocampus and participates in forming kainate receptor subtypes with Grik2 and KA2.
Activation of Grik1 induces intracellular calcium release and protein kinase C activation.
Excessive activation has been linked to psychiatric, neurological, and neurodegenerative disorders.
Multiple isoforms of Grik1 exist and may undergo RNA editing within the second transmembrane domain, influencing ion channel properties.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.