Thermo Fisher Scientific TNNT1 Polyclonal Antibody
TNNT1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 Immunocytochemistry에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 고순도 Affinity chromatography 정제 제품입니다. PBS/glycerol buffer에 보관되며 -20°C에서 안정적으로 저장 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TNNT1 (Accession P13805), corresponding to amino acid residues E24–D74 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2853518 |
Product Specific Information
This antibody detects endogenous levels of total TNNT1.
Target Information
The TNNT1 gene encodes a protein that is a subunit of troponin, a regulatory complex located on the thin filament of the sarcomere. Troponin regulates striated muscle contraction in response to intracellular calcium concentration changes. The complex consists of three subunits:
- Troponin C: binds calcium
- Troponin T: binds tropomyosin
- Troponin I: inhibitory subunit
TNNT1 is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5 (Amish nemaline myopathy), a neuromuscular disorder characterized by muscle weakness and rod-shaped inclusions in skeletal muscle fibers. This condition affects infants and can result in respiratory insufficiency, typically within the second year of life. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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