Thermo Fisher Scientific TMEM119 Monoclonal Antibody (CL8714)
인간 TMEM119 단백질을 인식하는 Mouse IgG1 단일클론 항체. Western blot, IHC, ICC/IF에 적합. 단백질 A로 정제된 액상형 비결합 항체로 1 mg/mL 농도. 미세아교세포 표지자로 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:5,000–1:10,000 |
| Immunocytochemistry (ICC/IF) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL8714 |
| Immunogen | Recombinant protein corresponding to Human TMEM119 (UniProt ID: Q4V9L6-1, range: 194–282) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.00 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2848948 |
Product Specific Information
Immunogen sequence:
GDGARMVEGR GAEEEEKGSQ EGDQEVQGHG VPVETPEAQE EPCSGVLEGA VVAGEGQGEL EGSLLLAQEA QGPVGPPESP CACSSVHPS
Target Information
Tmem119 encodes a single-pass type I transmembrane protein that interacts with various micro-RNAs and transcription factors such as SMAD1, SMAD5, and RUNX2.
It serves as a surface marker of microglia, distinguishing them from infiltrating macrophages. Microglial cells, restricted to the brain, are phagocytes involved in debris clearance and neuronal dendrite pruning. They exhibit functional plasticity, balancing neuroprotective and neurotoxic roles depending on their microenvironment.
Reactive microglia co-express Iba1 and have been linked to the differentiation of pathogenic A1-type astrocytes via secretion of Cq1, IL-1α, and TNF under LPS stimulation. These processes contribute to neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's disease, and multiple sclerosis.
Outside the neural system, Tmem119 may be involved in osteoblast differentiation and ossification.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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