Thermo Fisher Scientific CYP1A2 Monoclonal Antibody (OTI15E2), TrueMAB

Applications and Tested Dilution

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. These monooxygenases catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
CYP1A2 localizes to the endoplasmic reticulum, and its expression is induced by polycyclic aromatic hydrocarbons (PAHs), including those found in cigarette smoke.
The enzyme’s endogenous substrate is unknown, but it can metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates include caffeine, aflatoxin B1, and acetaminophen.
The transcript contains four Alu sequences flanked by direct repeats in the 3′ untranslated region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.