Thermo Fisher Scientific IL1RA Monoclonal Antibody (CRM17), FITC, eBioscience
인간 IL-1RA를 인식하는 CRM17 단클론 항체로, FITC 형광 표지되어 유세포 분석에 적합함. 0.5 mg/mL 농도의 액상 제품이며, PBS 완충액에 보존됨. 4°C 암소 보관, 동결 금지. 연구용으로만 사용 가능.
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Thermo Fisher Scientific IL1RA Monoclonal Antibody (CRM17), FITC, eBioscience™
Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 0.5 µg/test
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CRM17 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4 °C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_465375 |
Product Specific Information
The CRM17 antibody reacts with human interleukin‑1 receptor antagonist (IL‑1RA). IL‑1RA is produced by macrophages, monocytes, neutrophils, synovial and dermal fibroblasts. The 17 kDa soluble form (sIL‑1RA) is produced by hepatocytes.
IL‑1RA inhibits the release of both forms of IL‑1, suppresses IL‑2 secretion and receptor expression, and blocks prostaglandin E₂ synthesis in synovial cells as well as thymocyte proliferation.
- Applications Reported: Intracellular staining with flow cytometric analysis
- Applications Tested: Pre‑titrated and tested; use 5 µL (0.25 µg) per test
- Excitation / Emission: 488 nm / 520 nm (Blue Laser)
- Filtration: 0.2 µm post‑manufacturing filtered
Target Information
The IL‑1 receptor antagonist (IL1RA) gene encodes a cytokine receptor belonging to the interleukin‑1 receptor family. It binds IL‑1α, IL‑1β, and IL‑1 receptor type I (IL1R1/IL1RA) and mediates cytokine‑induced immune and inflammatory responses.
This gene forms part of a cytokine receptor cluster on chromosome 2q12 along with IL1R2, IL1RL2, and IL1RL1.
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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