Thermo Fisher Scientific ATF4 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive test control: HeLa cells
• Target localization: Cell membrane, Cytoplasm, Nucleus, Centrosome, Cytoskeleton, Microtubule organizing center

Immunogen sequence:
MTEMSFLSSE VLVGDLMSPF DQSGLGAEES LGLLDDYLEV AKHFKPHGFS SDKAKAGSSE WLAVDGLVSP SNNSKEDAFS GTDWMLEKMD LKEFDLDALL GIDDLETMPD DLLTTLDDTC DLFAPLVQET NKQPPQTVNP IGHLPESLTK PDQVAPFTFL QPLPLSPGVL SSTPDHSFSL ELGSEVDITE GDRKPDYTAY VAMIPQCIKE EDTPSDNDSG ICMSPESYLG SPQHSPSTRG SPNRSLPSPG VLCGSARPKP YDPPGEKMVA AKVKGEKLDK KLKKMEQNKT AATRYRQKKR AEQEALTGEC KELEKKNEAL KERADSLAKE IQYLKDLIEE VRKARGKKRV P

Target Information

This gene encodes a transcription factor originally identified as a mammalian DNA-binding protein that binds a tax-responsive enhancer element in the LTR of HTLV-1. It is also known as cAMP-response element binding protein 2 (CREB-2).
The encoded protein belongs to a family of DNA-binding proteins including AP-1, CREB, and CREB-like proteins. These transcription factors share a leucine zipper region involved in protein-protein interactions, located C-terminal to a basic amino acid stretch functioning as a DNA-binding domain.
Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 within a region containing a large inverted duplication.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.