Thermo Fisher Scientific Phospho-Androgen Receptor (Ser213, Ser210) Monoclonal Antibody (156C135.2)
Ser213/Ser210 인산화된 Androgen Receptor를 검출하는 Mouse monoclonal antibody. Western blot 및 IHC(paraffin)에 적합하며, 다양한 종(인간, 마우스, 랫 등)에 반응. 단백질 G 정제, PBS buffer에 0.05% sodium azide 포함.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1–4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:10–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 156C135.2 |
| Immunogen | Synthetic peptide corresponding to amino acids 207–221 (GRAREAS*GAPTSSKD) of human androgen receptor, containing the serine 213 phosphorylation |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2537739 |
Product Specific Information
Suggested positive control: IGF-1 stimulated LNCaP cells.
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is larger than 90 kDa and has three major functional domains:
- N-terminal domain
- DNA-binding domain
- Androgen-binding domain
AR acts as a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and stimulates transcription of androgen-responsive genes.
The AR signaling pathway is essential for development and function of male reproductive organs (prostate, epididymis) and also plays roles in nonreproductive tissues such as muscle, hair follicles, and brain. AR is a phosphoprotein that regulates MAP kinase signaling; inhibition of MEK1/2 correlates with changes in AR phosphorylation state.
Abnormalities in AR signaling are associated with diseases including prostate cancer, Kennedy’s disease, and male infertility. Mutations can lead to complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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