Thermo Fisher Scientific MiTF Monoclonal Antibody (21D1418)
MiTF 단백질을 인식하는 Thermo Fisher Scientific의 Mouse IgG1 단일클론 항체. Western blot, IHC 및 ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. Protein G 정제, 1 mg/mL 농도. 연구용으로만 사용.
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Thermo Fisher Scientific MiTF Monoclonal Antibody (21D1418)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–1.0 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 | - |
| Immunocytochemistry (ICC/IF) | 1–5 µg/mL | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 21D1418 |
| Immunogen | Synthetic peptide mapping to the 300–350 amino acid region of MITF |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2537732 |
Product Specific Information
Suggested positive control: A375 or RAW cells.
Target Information
MiTF (Microphthalmia-associated transcription factor) is a basic helix-loop-helix-leucine zipper (b-HLH-ZIP) transcription factor involved in pigmentation, mast cell, and bone development. Mutations in MiTF cause Waardenburg Syndrome type II in humans. In mice, loss of MiTF results in depigmentation, osteopetrosis, and immune cell defects. Two isoforms exist, differing by 66 amino acids at the N-terminus. Shorter forms (52–56 kDa) are expressed in melanocytes, while longer forms (60–70 kDa) are found in osteoclasts, B16 melanoma cells, mast cells, and heart tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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