Thermo Fisher Scientific IL-6 Receptor (CD126) Chimeric Recombinant Rabbit Monoclonal Antibody (D7715A7)
마우스 IL-6 수용체(CD126)에 특이적인 키메릭 재조합 토끼 단클론 항체. ICC/IF, Flow Cytometry 및 Functional/Inhibition Assay에 사용 가능. 단백질 A로 정제된 액상 형태로 제공되며, 장기 보관 시 -20°C에서 보관 권장.
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Thermo Fisher Scientific IL-6 Receptor (CD126) Chimeric Recombinant Rabbit Monoclonal Antibody (D7715A7)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 1:100 |
| Functional Assay (Functional) | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | D7715A7 |
| Immunogen | This antibody was raised by immunising Lewis rats with OKT4 cells. Target: IL-6 Receptor (CD126), UniProt ID: P22272-1, Antigen Range: 1–460 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074643 |
Product Specific Information
Specificity: This antibody is specific for murine IL-6R.
Target Information
Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response.
The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of multiple diseases, such as multiple myeloma, autoimmune diseases, and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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