Thermo Fisher Scientific p16INK4a Polyclonal Antibody
Mouse 및 Rat에서 반응하는 Rabbit Polyclonal 항체로, p16INK4a 단백질 검출용. WB, IHC, ICC, ELISA 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제된 고순도 제품. 세포주기 조절 관련 연구에 적합.
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1:100–1:2,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH, derived from a sequence within residues 50–150 of mouse p16INK4a (Swiss-Prot #P51480) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2291616 |
Product Specific Information
The target sequence has 93% sequence homology with rat, 86% with porcine, and 80% with human.
Target Information
This gene generates several transcript variants differing in their first exons. At least three alternatively spliced variants encode distinct proteins, two of which are CDK4 kinase inhibitors. Another transcript includes an alternate first exon located 20 Kb upstream, encoding an alternate open reading frame (ARF) that specifies a structurally unrelated protein. The ARF product stabilizes tumor suppressor p53 by interacting with and sequestering MDM2, preventing p53 degradation. Despite structural differences, both CDK inhibitor isoforms and ARF share a role in G1 cell cycle control. This gene is frequently mutated or deleted in various tumors and is an important tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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